4/16/2023 0 Comments Enzymex for pcThe endonuclease scission of magnetic particles functionalized with sequence-specific DNAs, which are associated on cantilevers, is followed by the magnetic force-amplified readout of the reactions by the nano-mechanical deflection/retraction of the cantilevers. Here is a short explanation available from Moldynlogic (Molecular Logic Machines by Electronic Excitations and Inter- and Intra- Molecular Quantum Dynamics), a EU project, which helped to fund the research described here today. The addition of two further enzymes - glucose oxidase and catalase - connected the two logical operations, making it possible to add together binary digits using the logic functions.īelow is a diagram showing endonuclease-based logic gates described in a previous work, "Endonuclease-based logic gates and sensors using magnetic force-amplified read out of DNA scission on cantilevers" (Credit: Itamar Willner et al.). The enzyme computer was used to perform two fundamental logic computations known as AND (where A and B must both equal one) and XOR (where A and B must have different values). The chemical result of the enzyme-powered reaction was determined optically. The presence of each chemical corresponded to a binary 1, while the absence represented a binary 0. Two chemical components - hydrogen peroxide and glucose - were used to represent input values (A and B). The team built their computer using two enzymes - glucose dehydrogenase (GDH) and horseradish peroxidase (HRP) - to trigger two interconnected chemical reactions. Here is a short description of the molecular computer built by a team led by Professor Itamar Willner of the Hebrew University of Jerusalem.
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